My acupuncturist/OMD recommended this (but at 50 mu dose). Tried 50 mu for a bottle, then switched to 30 mu for now at least a couple of months and don't fell a difference (cheaper). The stuff works well for me. I have an autoimmune arthritis and seem to have stool problems with the disease or/and medications, with both diarrhea or constipation. These seem to help. I bought another brand, but these seem to work better, with better stool formation and less bouts of diarrhea, good improvement, but not perfect, but worth the cost for the benefit. Was just on a antibiotic regimen of ciprofloxicin + flagyl for 10 days and went through with no gastrointestinal problems. Overall pleased.

PunMed search shows efficacy of Probiotics in particular IBS. Duration of treatment and best formulations (which bacteria) and dose appear to be still unknown. However, a study in 15 elderly patients showed positive effects on the immune system (by measuring natural killer cells in blood) at 3 weeks (Gill HS et all; search).

A few notes/comments from the questions section (my last purchase in June 2018):
-I cut a cap open, doesn't look like sustained release, just powder in a vegetable capsule [correction web site says sustained release]- see pic attached.
-The caps are vegetable and cellulose.
-Storage 77F (25C) or below. Best if refrigerated.
-Did not come shipped in a cooler.
-Expiration date was 1-1/2 years from purchase date (11/2019)
-Measured capsule to confirm 3/4 inch long and 1/4 inch across (on the large size)
-Lists as: gluten, dairy, and soy free
-Supplement Facts lists 11 strains, 4 Bifobacterium + 7 Lactobacillus strains = 11. However, there are 2 strains of B. cactus, thus 12 strains.
-Duration of treatment to assess treatment effect unknown, but the study cited above suggests at least 3 weeks in elderly humans.

These Probiotics have changed my life. I would highly reccomend them to anyone with tummy issues.

These products are the best.i wish the 50 billion cultures with 10 strains weren't so expensive but these 30 billion do just as great.its ok to take two of them about 20-30 mins apart from each other but this is the best brand out there for a great price.

Been taking this for yrs so I figured I may as well have it on auto ship. Wish I could afford a larger dose (I felt better with more) but budget doesn't allow. Everyone should be taking this. It really is the bacteria in ur intestines

I suffer from mild IBS. I say mild, because my family all have it and I seem to be the least affected, if that helps anyone reading this decide.

This product is the best I have found at alleviating my symptoms. It keeps me regular, and the bloating and gas are almost "normal" now. There's not much else to say, really, other than I wish I'd found it a long time ago. I've tried plenty other brands and keep coming back to this specific product.